ABOUT LDN-27219 SIDE EFFECTS

One particular specially intriguing compound is LDN-27219. Although most tTG inhibitors are made to bind to the protein crosslinking Lively internet site, LDN-27219 instead binds on the nucleotide binding pocket of your enzyme when it can be in its shut-condition conformation, and stabilizes that conformation to circumvent crosslinking activity.78